Medical Weight Loss

SEMAGLUTIDE

GLP-Glucagon Like Peptide 1

·       Used for type 2 diabetes and obesity.  Has demonstrated broad metabolic benefits beyond glucose control

EFFECTS

·       Reduced appetite: targets brain receptors in the hypothalamus to reduce hunger

·       Delayed gastric emptying: Keeping you feeling full longer after meals

·       Managing blood sugar: It stimulates insulin production from the pancreas only when glucose levels are high

·       Glucagon Suppression: Binds to GLP-1 receptors in the pancreas which suppresses the release of glucagon

·       Energy Expenditure and lipid metabolism: Semaglutide has been shown to increase expenditure and promote fat burning reducing body weight. Has a positive impact on lipid metabolism improving cholesterol and triglyceride levels

·       Cardiovascular: May improve cardiovascular outcome in people with diabetes

SIDE EFFECTS

·       Common: nausea, vomiting, constipation, diarrhea, injections site reactions

·       Uncommon: Pancreatitis, gallstones, kidney problems, allergic reactions

·       Contraindications: A personal or family history of medullary thyroid cancer or multiple endocrine neoplasia. Animal studies have linked these drugs with thyroid tumors. Breastfeeding or pregnant

DOSING

·       Injection:  0.25mg SubQ once weekly for 4 weeks. Titrate up as directed.

·       Oral: 3 mg by mouth once daily for 30 days. Titrate up as directed.

EVIDENCE

·       Type 2 diabetes: SUSTAIN 1-10. PIONEER 1-10.

·       Obesity: STEP 1-5. STEP TEENS.

·       Cardiovascular disease: SUTAIN-6, SELECT

·       Chronic Kidney disease: FLOW